Detailed view for PF3D7_1145500

Basic information

TDR Targets ID: 1931
Plasmodium falciparum, ABC transporter B family member 3, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.2493 | Length (AA): 833 | MW (Da): 99349 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00005   ABC transporter
PF00664   ABC transporter transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0042626   ATPase activity, coupled to transmembrane movement of substances  
GO:0020011   apicoplast  
GO:0016021   integral to membrane  
GO:0005739   mitochondrion  
GO:0017111   nucleoside-triphosphatase activity  
GO:0016887   ATPase activity  
GO:0005524   ATP binding  
GO:0000166   nucleotide binding  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
588 847 2ghi (A) 2 256 29.00 0 1 0.7 -1.34
593 843 1jj7 (A) 492 742 23.00 0 1 0.66 -1.43
600 870 1z47 (A) 11 273 19.00 0 0.98 0.52 -0.97
604 872 1g29 (1) 4 271 17.00 0 1 0.46 -0.66
146 828 4f4c (A) 655 1299 21.00 0 1 0.779828 1.62
588 829 2ghi (A) 2 238 30.00 0 1 0.737416 -0.75
593 828 2ixe (A) 469 703 27.00 0 1 0.747213 -1.02
619 827 3d31 (A) 13 211 33.00 0.00000000022 1 0.494 0.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Oocyst. Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_152077)

Species Accession Gene Product
Plasmodium berghei PBANKA_0903500   ABC transporter B family member 3, putative
Plasmodium falciparum PF3D7_1145500   ABC transporter B family member 3, putative
Plasmodium knowlesi PKNH_0943400   ABC transporter B family member 3, putative
Plasmodium vivax PVX_092880   ABC transporter B family member 3, putative
Plasmodium yoelii PY06546   transport protein-related

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0107 0.2982 0.2976
0.0096 0.2671 0
0.0091 0.286 0
0.0105 0.2581 0.0014
0.0119 0.2763 0
0.0068 0.2634 0
0.0074 0.2621 0.2491
0.013 0.28 0
0.01 0.2525 0
0.0074 0.2667 0.2495
0.0117 0.2609 0
0.0101 0.297 0.297
0.0055 0.2884 0.2884
0.0101 0.2856 0
0.0061 0.2824 0
0.0064 0.2606 0.2232
0.0082 0.2995 0.5092
0.0125 0.2942 0
0.0086 0.2639 0
0.0065 0.2748 0.269
0.0102 0.2778 0.2725
0.0204 0.2853 0.3044
0.005 0.2958 0
0.0077 0.2708 0
0.0065 0.2573 0
0.0157 0.2814 0.5243
0.0089 0.2637 0
0.0057 0.2538 0.2443
0.0199 0.2537 0.2994
0.0137 0.2918 0.2678
0.0086 0.2635 0.2346
0.0097 0.2874 0
0.0122 0.2698 0.2698
0.0054 0.2631 0
0.0074 0.2596 0
0.0053 0.2821 0
0.0113 0.2726 0.2677
0.0254 0.2524 0.176
0.0099 0.2891 0.278
0.0038 0.2684 0
0.0101 0.3024 0
0.0126 0.3471 0.4107
0.0079 0.2588 0
0.0178 0.289 0.5648
0.0206 0.2586 0.2206
0.0087 0.2825 0
0.0199 0.2537 0.2994
0.0068 0.2504 0
0.0055 0.2531 0
0.0123 0.2787 0
0.0068 0.2634 0
0.0064 0.2602 0
0.0226 0.2607 0.1574
0.0124 0.2765 0
0.01 0.2539 0
0.0117 0.2749 0
0.0101 0.297 0.297
0.0038 0.2684 0
0.0029 0.2983 0.3702
0.0053 0.2821 0
0.0177 0.2919 0.4309
0.0087 0.2619 0
0.011 0.2652 0.2652
0.0103 0.2692 0
0.0129 0.2892 0.2712
0.0085 0.2691 0
0.003 0.2602 0.2457
0.0042 0.2624 0
0.0074 0.2584 0
0.0177 0.2919 0.4309
0.0038 0.2692 0.4673
0.0133 0.2801 0
0.0107 0.2591 0
0.0029 0.2983 0.3702
0.0032 0.2584 0.2433
0.0136 0.2913 0.2749
0.0088 0.2555 0.2555
0.0029 0.2983 0.3702
0.0126 0.2956 0
0.0086 0.2826 0
0.0109 0.2892 0
0.0206 0.2785 0.2732
0.0038 0.2692 0.4673
0.0105 0.2629 0.2629
0.0029 0.2983 0.3702
0.0086 0.2819 0
0.0113 0.283 0
0.0212 0.2836 0.1869
0.0117 0.2589 0.2781
0.0226 0.2574 0.1564
0.0271 0.2507 0.2166
0.0146 0.2695 0.2381
0.0063 0.3239 0.3239
0.0088 0.2555 0.2555
0.009 0.2658 0
0.0133 0.2951 0
0.0161 0.2787 0.2722

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1145500 (Plasmodium falciparum), ABC transporter B family member 3, putative
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